We present a practical guide and step-by-step flowchart for establishing uncertainty intervals for key model outcomes in a simulation model in the face of uncertain parameters.The process starts with Powell optimization to find a set of uncertain parameters (the optimum parameter set or OPS) that minimizes the model fitness error relative to histor
Exercise induced bronchoconstriction (EIB) describes the transient narrowing of the airways that follows vigorous exercise.It commonly occurs in children and adults who have asthma and ice blue graphic tee in elite athletes.The primary stimulus is proposed to be loss of water, by evaporation, from the airway surface due to conditioning inspired air
Abstract Background Retrocaval ureter was diagnosed in a woman complaining read more of ureteric pain in the last trimester of pregnancy.We describe the rationale behind the administration of epidural analgesia for her colic attack.Case presentation A 41-year-old pregnant woman was hospitalized with a diagnosis of a marginal placenta previa at 34 w
It is estimated that half of all proteins expressed in eukaryotic cells are transferred across or into at least one cellular membrane to reach their functional location.Protein translocation into the endoplasmic reticulum (ER) is critical to the subsequent ice blue graphic tee localization of secretory and transmembrane proteins.A vital component o